Pellino enhances innate immunity in Drosophila
نویسندگان
چکیده
The innate immune response is a defense mechanism against infectious agents in both vertebrates and invertebrates, and is in part mediated by the Toll pathway. Toll receptor activation upon exposure to bacteria causes stimulation of Pelle/IRAK kinase, eventually resulting in translocation of the transcription factor NF-kappaB to the nucleus. Here we show that Pellino, a highly conserved protein interacting with activated Pelle/IRAK, acts as a positive regulator of innate immunity in Drosophila.
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عنوان ژورنال:
- Mechanisms of Development
دوره 127 شماره
صفحات -
تاریخ انتشار 2010